" /> Autologous CAR-mbIL15-Safety Switch T-cells PRGN-3006 - CISMeF





Preferred Label : Autologous CAR-mbIL15-Safety Switch T-cells PRGN-3006;

NCIt synonyms : Autologous CAR-T Cells PRGN 3006;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to co-express three transgenes using the Sleeping Beauty (SB) transposon system, including a chimeric antigen receptor (CAR) targeting an undisclosed tumor-associated antigen (TAA), a membrane-bound IL-15 (mbIL15) and a safety/kill switch, with potential immunostimulating and antineoplastic activities. Upon introduction of the autologous PRGN-3006 T-cells into the patient, these T-cells target, bind to and induce selective toxicity in cells expressing this particular TAA. IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8 memory T-cells. Use of mbIL15 preserves T stem-cell memory (TSCM) through sustained IL-15 signaling, improves T-cell persistence and potentiates the immune response against tumor cells. The safety switch can promote selective elimination of the CAR-T cells. The SB system permits integration of the CAR, the IL-15 fusion variant and safety switch transgenes into T-cells without the need for viral vectors and accelerates the manufacturing process.;

Molecule name : PRGN 3006; PRGN-3006;

NCI Metathesaurus CUI : CL969928;

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10/05/2024


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