Autologous CRISPR-edited Tumor Infiltrating Lymphocytes GT316

Preferred Label : Autologous CRISPR-edited Tumor Infiltrating Lymphocytes GT316;

NCIt synonyms : Autologous TILs GT316; Autologous CRISPR-edited TILs GT316; CRISPR/Cas9-engineered TILs GT316; Autologous Tumor Infiltrating Lymphocytes GT316;

NCIt definition : A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from each patient's resected tumor and edited with the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) system to eliminate the expression of as of yet not elucidated immunoregulatory targets, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, autologous CRISPR-edited TILs GT316 specifically recognize and kill the patient's tumor cells. The knockout of the immunoregulatory targets may enhance the proliferation and cytokine release of the TILs.;

Molecule name : GT-316; GT 316;

NCI Metathesaurus CUI : CL1926428;

Details

Origin ID

C204173;

UMLS CUI

C5908040;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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