" /> Autologous Anti-B7-H3 CAR T Cells CAR.B7-H3T - CISMeF





Preferred Label : Autologous Anti-B7-H3 CAR T Cells CAR.B7-H3T;

NCIt synonyms : Autologous Anti-CD276 CAR-T Cells CAR.B7-H3T; CAR.B7-H3T Cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-B7-H3 CAR T cells CAR.B7-H3T target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis.;

NCI Metathesaurus CUI : CL1792335;

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15/05/2024


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