Autologous Anti-KK-LC-1 TCR-expressing T-cells

Preferred Label : Autologous Anti-KK-LC-1 TCR-expressing T-cells;

NCIt synonyms : KK-LC-1 TCR T Cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) Kita-Kyushu lung cancer antigen-1 (KK-LC-1), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-KK-LC-1 TCR-expressing T-cells specifically target and bind to KK-LC-1-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of KK-LC-1-expressing tumor cells. KK-LC-1, a cancer germline (CG) antigen, is expressed in a variety of epithelial cancers and has restricted expression in normal tissues.;

NCI Metathesaurus CUI : CL1664836;

Details

Origin ID

C181918;

UMLS CUI

C5557362;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Kita-Kyushu Lung Cancer Antigen 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients