Total Tumor mRNA-pulsed Tumor-specific Ex vivo-expanded Autologous Lymphocyte Transfer Cells

Preferred Label : Total Tumor mRNA-pulsed Tumor-specific Ex vivo-expanded Autologous Lymphocyte Transfer Cells;

NCIt synonyms : Autologous TTRNA mRNA-loaded Lymphocyte Transfer Cells; TTRNA-xALT; TTRNA-xALT Cells;

NCIt definition : A preparation of ex vivo expanded, autologous lymphocyte transfer cells (xALTs) that are loaded with total tumor RNA (TTRNA) derived from autologous tumor cells, with potential immunostimulatory and antineoplastic activities. Upon re-infusion of the TTRNA-loaded ALTs into the patient, these ALTs may elicit a highly specific cytotoxic T-lymphocyte (CTL) response against the tumor-associated antigens (TAAs) encoded by the TTRNA.;

NCI Metathesaurus CUI : CL562714;

Details

Origin ID

C155969;

UMLS CUI

C4733660;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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