Autologous PD1-inhibiting Anti-CD19 4-1BB CAR T Cells - CISMeF
Autologous PD1-inhibiting Anti-CD19 4-1BB CAR T CellsNCIt concept
Preferred Label : Autologous PD1-inhibiting Anti-CD19 4-1BB CAR T Cells;
NCIt synonyms : Autologous iPD1 CD19 eCAR T Cells;
NCIt definition : A preparation of autologous T-lymphocytes that are transduced with a lentiviral vector
encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen
(TAA) cluster of differentiation 19 (CD19) linked to the intracellular signaling domain
of 4-1BB (CD137) that also encodes a cell-intrinsic programmed cell death 1 (PD1;
PDCD1; CD279; programmed death-1) short/small hairpin RNA (shRNA)-expressing cassette,
with potential immunomodulating and antineoplastic activities. Upon administration
of the autologous PD1-inhibiting anti-CD19 4-1BB CAR T-cells, these cells target,
bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen
is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.
The shRNA silences expression of PD1, abrogates T-cell exhaustion, increases CAR T-cell
activity and enhances tumor cytotoxicity. Expression of PD-1, an inhibitory receptor
expressed on activated T-cells, plays a key role in CTL suppression, T-cell exhaustion
and CTL apoptosis.;