NCIt definition : A fusion protein consisting of the heavy-chains of the human antibody NHS76, raised
against DNA released by necrotic tumor cells, and fused to two molecules of a genetically
modified human interleukin-12 (IL-12) with potential immunostimulating and antineoplastic
activities. Upon administration, the antibody moiety of immunocytokine NHS-IL12 binds
to DNA released from necrotic tumor cells located primarily at the core of necrotic
solid tumors, thereby delivering the IL-12 moiety. In turn, the IL-12 moiety of this
agent stimulates the host immune system to mount an immune response against tumor
cells, thereby inhibiting tumor growth. IL-12 is a proinflammatory cytokine with numerous
immunoregulatory functions and may augment host immune responses to tumor cells. By
targeting tumor cells, NHS-IL-12 may reduce the toxicity associated with systemic
administration of recombinant human IL-12.;