NCIt definition : A recombinant fusion protein consisting of the heavy-chains of the human immunoglobulin
G1 (IgG1) monoclonal antibody NHS76, raised against DNA released by necrotic tumor
cells, and fused to two molecules of a genetically modified human interleukin-12 (IL-12)
with potential immunostimulating and antineoplastic activities. Upon administration,
the antibody moiety of immunocytokine PDS01ADC binds to DNA released from necrotic
tumor cells located primarily at the core of necrotic solid tumors, thereby delivering
the IL-12 moiety. In turn, the IL-12 moiety of this agent stimulates the host immune
system to mount an immune response against tumor cells, thereby inhibiting tumor growth.
IL-12 is a proinflammatory cytokine with numerous immunoregulatory functions and may
augment host immune responses to tumor cells. By targeting tumor cells, PDS01ADC may
reduce the toxicity associated with systemic administration of recombinant human IL-12.;