NCIt definition : Autologous tumor infiltrating lymphocytes (TILs) harvested directly from the infiltrate
of a patient's tumor and treated with an inhibitor of the serine/threonine kinases
Akt-1 and -2 (Akti-1/2) during ex vivo expansion, with potential antineoplastic activity.
Upon reintroduction into the patient, the Akti-1/2-treated TILs recognize and kill
cancer cells. Akt inhibition promotes the immunologic memory of the TILs and enhances
their expansion, in vivo long-term persistence and antitumor activity.;