" /> Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-EGFRt-expressing CD4 /CD8 T-lymphocytes - CISMeF





Preferred Label : Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-EGFRt-expressing CD4 /CD8 T-lymphocytes;

NCIt synonyms : Anti-BCMA-CAR-4-1BB-CD3zeta-EGFRt SIN Lentiviral Vector-transduced Autologous CD4 /CD8 T-lymphocytes; Autologous BCMA-specific CAR-4-1BB-CD3zeta-EGFRt-expressing CD4 /CD8 T Lymphocytes;

NCIt definition : A preparation of an approximately equal ratio of autologous CD4- and CD8-positive T-lymphocytes that have been ex vivo transduced with a genetically-engineered self-inactivating (SIN) lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) specific for the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused to the co-stimulatory domain of 4-1BB (CD137), the CD3-zeta (CD3z) T-cell signaling domain, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-BCMA-CAR-4-1BB-CD3zeta-EGFRt-expressing CD4 /CD8 T-lymphocytes specifically recognize and induce selective toxicity against BCMA-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt facilitates both in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells.;

NCI Metathesaurus CUI : CL550771;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
15/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.