NCIt synonyms : Anti-CD19 Autologous CAR T-cells ET019002; ET019002-T Cells;
NCIt definition : A preparation of autologous T-lymphocytes that have been transduced with a lentiviral
vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable
fragment (scFv) of anti-CD19, coupled to the costimulatory domain of CD28, with potential
immunostimulating and antineoplastic activities. Upon transfusion, the autologous
anti-CD19 CAR-CD28 T-cells ET019002 target, bind to, and induce selective toxicity
in CD19-expressing B-cells. The CD19 antigen is a B-cell-specific cell surface antigen
expressed in all B-cell lineage malignancies.;