NCIt definition : Autologous T-lymphocytes that have been transduced with a lentiviral vector to express
a chimeric antigen receptor (CAR) consisting of a humanized single chain variable
fragment (scFv) of anti-CD19 coupled to the cytoplasmic portion of the zeta chain
of the human T-cell receptor (CD3zeta) and the co-stimulatory molecule 4-1BB (CD137),
with potential immunostimulating and antineoplastic activities. Upon re-introduction
into the patient, the autologous anti-CD19 CAR TCR-zeta/4-1BB-transduced T-lymphocytes
huCART19 target and bind to CD19-expressing neoplastic B-cells. This results in a
cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, resulting
in tumor cell lysis. CD19 (cluster of differentiation 19) is a B-cell-specific cell
surface antigen overexpressed in B-cell lineage tumors. Incorporation of the co-stimulatory
signaling domains increases human T-cell function, expansion, and survival.;