Autologous Polyclonal Tumor Infiltrating Lymphocytes LYL845

Preferred Label : Autologous Polyclonal Tumor Infiltrating Lymphocytes LYL845;

NCIt synonyms : Autologous TILs LYL845;

NCIt definition : A preparation of autologous, epigenetically reprogrammed, polyclonal tumor infiltrating lymphocytes (TILs), with potential immunomodulating and antineoplastic activities. The autologous TILs LYL845 are prepared and expanded ex vivo by co-culturing autologous tumor cells with specific Epi-R cell culture media containing optimized cytokine composition and cell activation which creates TILs enriched with CD8-positive T-cells with diverse tumor-reactive clones and an enhanced proportion of stem-like T-cells. Upon administration, the autologous TILs LYL845 may target and kill tumor cells and secrete pro-inflammatory cytokines. LYL845 shows increased durability of expanded TILs, enhanced polyclonality and increased tumor-reactive cytolytic T-cells compared to TILs derived from the standard process.;

Molecule name : LYL-845; LYL 845;

NCI Metathesaurus CUI : CL1912922;

Details

Origin ID

C192699;

UMLS CUI

C5785378;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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