CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes

Preferred Label : CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes;

NCIt synonyms : CART-33 TCR zeta:CD137 Cells; Anti-CD33 TCR zeta:CD137 CAR T Cells; CART33 TCR zeta:CD137 Cells;

NCIt definition : Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD33 scFv (single chain variable fragment) coupled to the signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR retroviral vector-transduced autologous T lymphocytes target CD33-expressing tumor cells and induce selective toxicity in CD33-expressing tumor cells. Following binding to CD33, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. CD33 is expressed on normal non-pluripotent hematopoietic stem cells as well as on myeloid leukemia cells.;

NCI Metathesaurus CUI : CL449450;

Details

Origin ID

C107190;

UMLS CUI

C3831168;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Myeloid Cell Surface Antigen CD33 [NCIt concept]

Keyword's position in hierarchy(ies) :

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