Preferred Label : hTERT-encoding DNA Vaccine INVAC-1;
NCIt related terms : INVAC-1, A DOUBLE STRANDED DNA PLASMID VACCINE CONSTRUCT ENCODING UBIQUITIN-HUMAN
TELOMERASE REVERSE TRANSCRIPTASE (HTERT) FUSION PROTEIN;
NCIt definition : A DNA vaccine consisting of a plasmid encoding a modified, inactive form of the human
telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase
which synthesizes telomeric DNA at the chromosome ends, fused to ubiquitin, with potential
immunostimulating and antineoplastic activities. Upon intradermal vaccination of the
hTERT encoding DNA vaccine INVAC-1 in combination with electroporation, hTERT protein
is expressed and activates the immune system to mount a cytotoxic T-cell (CTL) response
against telomerase-expressing tumor cells, which may result in tumor cell death. Telomerase
prolongs the functional lifespan of cells via the restoration and maintenance of telomere
length. Abnormally activated in tumorigenesis, telomerase is expressed in the majority
of human cancer cells, but its expression is low or non-existent in normal cells.
hTERT conjugation to ubiquitin, a 76 amino-acid peptide involved in the regulation
of normal protein intracellular turnover in the cytoplasm, enhances proteasome-dependent
degradation of the hTERT protein, increases hTERT presentation by major histocompatibility
complex (MHC) class I molecules and results in an increased immune response against
hTERT.;
UNII : S8GQZ8LF0D;
CAS number : 1708137-44-3;
Molecule name : INVAC-1;
Origin ID : C119737;
UMLS CUI : C3896833;
Semantic type(s)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
