Telomere Reverse Transcriptase

Preferred Label : Telomere Reverse Transcriptase;

NCIt synonyms : EC 2.7.7.49; TERT; Telomerase-Associated Protein 2; TP2; HEST2; Telomerase Catalytic Subunit; Telomerase Reverse Transcriptase Protein;

NCIt definition : Telomerase reverse transcriptase (1132 aa, 127 kDa) is encoded by the human TERT gene. This protein plays a role in both the replication and maintenance of telomeres.;

Details

Origin ID

C20183;

UMLS CUI

C0754515;

Automatic exact mappings (from CISMeF team)
- telomerase [MeSH Descriptor]
- telomerase catalytic subunit [MeSH concept]
Currated CISMeF NLP mapping
- Telomerase reverse transcriptase [OMIM gene]
- telomerase reverse transcriptase [ORDO Gene]
OMIM relation
- Telomerase reverse transcriptase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TERT protein, human [MeSH Supplementary Concept]
- TERT protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Polymerase Gene [NCIt concept]
- TERT Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- IL2/PI3K Signaling Pathway [NCIt concept]
- Regulation of Apoptosis Pathway [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- Telomere Pathway [NCIt concept]
gene_product_is_physical_part_of
- Telomerase [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Polymerization [NCIt concept]
- Reverse Transcription Process [NCIt concept]
- Telomere Maintenance [NCIt concept]
is_target
- UV1 Telomerase Peptide Vaccine [NCIt concept]
- hTERT Vaccine V934/V935 [NCIt concept]
- hTERT-LAMP mRNA-loaded Autologous Dendritic Cell Vaccine GRNVAC1 [NCIt concept]
- hTERT-encoding DNA Vaccine INVAC-1 [NCIt concept]
- hTERT/Survivin/CMV Multipeptide Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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