Preferred Label : Rocapuldencel-T;
NCIt synonyms : Renal Tumor RNA CD40L-Transfected Dendritic Cell Vaccine;
NCIt definition : A cancer vaccine in which autologous dendritic cells are transfected with patient-specific
renal cell carcinoma (RCC) RNA and a synthetic, truncated human CD40 ligand (CD40L)
RNA with potential immunostimulatory and antineoplastic activities. Individual RCC-specific
RNA, encoding a unique repertoire of tumor-associated antigens (TAAs) (including telomerase
reverse transcriptase, G250, and oncofetal antigen) is electroporated into autologous
dendritic cells (DCs), transfected with synthetic RNA that encodes a truncated version
of the T-cell protein CD40L; the transfected autologous DCs express and process both
patient-specific RCC TAAs and the truncated CD40L protein. When reintroduced back
to the patient, rocapuldencel-T may elicit a highly specific cytotoxic T-cell (CTL)
response against RCC cells expressing the patient-specific RCC TAA repertoire. The
signal cascade initiated by stimulation of the truncated, ectopically expressed co-stimulatory
molecule CD40L results in the secretion of the inflammatory cytokine IL-12 downstream.;
UNII : 8I9S6401XZ;
Molecule name : AGS-003; CMN-001;
NCI Metathesaurus CUI : CL387046;
Origin ID : C77907;
UMLS CUI : C4688385;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
