NCIt definition : A synthetic, peptide cancer vaccine directed against the human telomerase reverse
transcriptase catalytic subunit (hTERT) with potential immunomodulating activity.
Vaccination with the UV1 telomerase peptide may stimulate cytotoxic T-cells to recognize
and kill telomerase-expressing cells. Telomerase, a reverse transcriptase normally
repressed in healthy cells, is overexpressed in most cancer cells and plays a key
role in cellular proliferation.;