Alternative titles and symbols : Telomerase catalytic subunit; TCS1; EST2;
Description : Human telomeres consist of many kilobases of (TTAGGG)n together with various associated
proteins. Small amounts of these terminal sequences are lost from the tips of the
chromosomes each S phase because of incomplete DNA replication, but de novo addition
of TTAGGG repeats by the enzyme telomerase compensates for this loss. Many human cells
progressively lose terminal sequence with cell division, a loss that correlates with
the apparent absence of telomerase in these cells (Kipling, 1995).;