Preferred Label : hTERT-LAMP mRNA-loaded Autologous Dendritic Cell Vaccine GRNVAC1;
NCIt synonyms : hTERT-LAMP mRNA-loaded Autologous DC Vaccine GRNVAC1;
NCIt definition : A cancer vaccine containing autologous dendritic cells (DCs) that are pulsed with
mRNA encoding the tumor-associated antigens (TAAs) human telomerase reverse transcriptase
(hTERT) and lysosome-associated membrane protein 1 (LAMP1), with potential immunostimulatory
and antineoplastic activities. Upon administration, hTERT-LAMP mRNA-loaded autologous
DC Vaccine GRNVAC1 may elicit a cytotoxic T-lymphocyte (CTL) response against tumor
cells expressing hTERT and LAMP1. hTERT, the catalytic subunit of human telomerase,
is upregulated in certain tumor cell types and plays an important role in tumor cell
growth and survival. LAMP1, overexpressed on a variety of tumor cells, plays a key
role in cell-cell adhesion and migration.;
Molecule name : GRNVAC1;
NCI Metathesaurus CUI : CL376181;
Origin ID : C116888;
UMLS CUI : C3896847;
Semantic type(s)
- concept_is_in_subset
- has_target
