Telomerase - CISMeF

Preferred Label : Telomerase;

NCIt definition : A reverse transcriptase responsible for maintaining the telomere length of replicating cells. Telomerase recognizes a telomere-specific GC rich sequence and adds telomeric repeats by using and RNA template.;

Alternative definition : NCI-GLOSS: An enzyme in cells that helps keep them alive by adding DNA to telomeres (the ends of chromosomes). Each time a cell divides, the telomeres lose a small amount of DNA and become shorter. Over time, the chromosomes become damaged and the cells die. Telomerase helps keep this from happening. Cancer cells usually have more telomerase than most normal cells.;

Codes from synonyms : CDR0000643089;

Détails

Origin ID

C17470;

UMLS CUI

C0087071;

Automatic exact mappings (from CISMeF team)
- telomerase [EMDN type]
- telomerase [medical devices type]
CISMeF manual mappings
- telomerase [MeSH concept]
- telomerase [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- telomerase [MeSH concept]
- telomerase [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Polymerase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_chemical_classification
- Reverse Transcriptase [NCIt concept]
gene_product_is_biomarker_of
- Neuroblastoma [NCIt concept]
gene_product_is_biomarker_type
- Prognostic Biomarker [NCIt concept]
gene_product_plays_role_in_biological_process
- Telomere Maintenance [NCIt concept]
has_gene_product_element
- Telomerase Cajal Body Protein 1 [NCIt concept]
- Telomerase Protein Component 1 [NCIt concept]
- Telomerase RNA Component [NCIt concept]
- Telomere Reverse Transcriptase [NCIt concept]
is_target
- Imetelstat Sodium [NCIt concept]
- Suratadenoturev [NCIt concept]
- Synthetic hTERT DNA Vaccine INO-1400 [NCIt concept]
- Synthetic hTERT DNA Vaccine INO-1401 [NCIt concept]
- Transgenic Lymphocyte Immunization Vaccine [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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