Preferred Label : Suratadenoturev;
NCIt synonyms : Telomelycin; Telomerase-specific Type 5 Adenovirus OBP-301;
NCIt definition : A replication-competent oncolytic, telomerase-specific adenovirus serotype 5 (Ad5),
with potential antineoplastic activity. Suratadenoturev contains the human telomerase
reverse transcriptase (hTERT) gene promoter sequence that drives the expression of
the E1A and E1B genes, and is linked to an internal ribosomal entry site (IRES). Upon
administration, OBP-301 selectively infects and replicates in cancer cells that are
expressing telomerase, which causes cell lysis. This adenovirus does not infect or
replicate in normal, healthy cells. OBP-301 may also potentially be used as a chemosensitizer.
hTERT, which encodes for the catalytic protein subunit of telomerase, is overexpressed
in a variety of cancer cell types but not in normal, healthy cells. The insertion
of an IRES further improves selectivity towards telomerase-expressing cancer cells.;
UNII : FV0JG1SX76;
CAS number : 1268642-13-2;
Drug name : Telomelysin;
Molecule name : OBP-301;
Origin ID : C119617;
UMLS CUI : C5446290;
Semantic type(s)
- concept_is_in_subset
- has_target
