Preferred Label : Synthetic hTERT DNA Vaccine INO-1400;
NCIt definition : A DNA vaccine consisting of a plasmid encoding the full-length sequence of the tumor-associated
antigen (TAA) human telomerase reverse transcriptase (hTERT), which is the catalytic
subunit of human telomerase and synthesizes telomeric DNA at the chromosome ends,
containing two immunogenic mutations, with potential immunostimulating and antineoplastic
activities. Upon intradermal vaccination of the hTERT encoding DNA vaccine INO-1400
in combination with electroporation, hTERT protein is expressed and activates the
immune system to mount a cytotoxic T-cell (CTL) response against telomerase-expressing
tumor cells, which may result in tumor cell death. Telomerase prolongs the functional
lifespan of cells via the restoration and maintenance of telomere length. Abnormally
activated in tumorigenesis, telomerase is expressed in the majority of human cancer
cells, but its expression is low or non-existent in normal cells.;
Molecule name : INO-1400;
Origin ID : C120118;
UMLS CUI : C3896835;
Semantic type(s)
- concept_is_in_subset
- has_target
