Imetelstat Sodium

Preferred Label : Imetelstat Sodium;

NCIt synonyms : DNA, d(3'-amino-3'-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A), 5'-[O-[2-hydroxy-3- [(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate], Sodium Salt (1:13);

NCIt definition : The sodium salt of imetelstat, a synthetic lipid-conjugated, 13-mer oligonucleotide N3' P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the template region of telomerase RNA (hTR), imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a telomerase template antagonist), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding. Inhibition of telomerase activity in tumor cells by imetelstat results in telomere shortening, which leads to cell cycle arrest or apoptosis.;

UNII : 2AW48LAZ4I;

CAS number : 1007380-31-5;

Drug name : Rytelo;

Molecule name : GRN163L, Sodium Salt;

Chemical formula : C148H198N68O53P13S13.13Na;

Details

Origin ID

C84511;

UMLS CUI

C1708156;

Currated CISMeF NLP mapping
- Imetelstat sodium [SMS substance]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Imetelstat [NCIt concept]
has_target
- Telomerase [NCIt concept]
is_salt_form_of
- Imetelstat [NCIt concept]

Keyword's position in hierarchy(ies) :

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