NCIt definition : The sodium salt of imetelstat, a synthetic lipid-conjugated, 13-mer oligonucleotide
N3' P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary
to the template region of telomerase RNA (hTR), imetelstat acts as a competitive enzyme
inhibitor that binds and blocks the active site of the enzyme (a telomerase template
antagonist), a mechanism of action which differs from that for the antisense oligonucleotide-mediated
inhibition of telomerase activity through telomerase mRNA binding. Inhibition of telomerase
activity in tumor cells by imetelstat results in telomere shortening, which leads
to cell cycle arrest or apoptosis.;
UNII : 2AW48LAZ4I;
CAS number : 1007380-31-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1007380-31-5
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