NCIt definition : A synthetic lipid-conjugated, 13-mer oligonucleotide N3'-P5'-thio-phosphoramidate
with potential antineoplastic activity. Complementary to the template region of telomerase
(hTR) RNA, imetelstat acts as a competitive enzyme inhibitor that binds and blocks
the active site of the enzyme (a telomerase template antagonist), a mechanism of action
which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase
activity through telomerase mRNA binding. Inhibition of telomerase activity in tumor
cells by imetelstat results in telomere shortening, which leads to cell cycle arrest
or apoptosis.;
UNII : F60NE4XB53;
CAS number : 868169-64-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 868169-64-6
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