" /> Imetelstat - CISMeF





Preferred Label : Imetelstat;

NCIt synonyms : DNA, d(3'-amino-3'-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A), 5'-[O-[2-hydroxy-3- [(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate]; GRN163L;

NCIt definition : A synthetic lipid-conjugated, 13-mer oligonucleotide N3'-P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the template region of telomerase (hTR) RNA, imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a telomerase template antagonist), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding. Inhibition of telomerase activity in tumor cells by imetelstat results in telomere shortening, which leads to cell cycle arrest or apoptosis.;

UNII : F60NE4XB53;

CAS number : 868169-64-6;

Molecule name : GRN-163L; GRN 163L;

Chemical formula : C148H211N68O53P13S13;

Codes from synonyms : 270;

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Keyword's position in hierarchy(ies) : arborescence

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31/05/2025


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