Preferred Label : Synthetic hTERT DNA Vaccine INO-1401;
NCIt synonyms : SynCon TERT;
NCIt definition : A DNA vaccine consisting of a plasmid encoding a synthetic, full-length sequence of
the tumor-associated antigen (TAA) telomerase reverse transcriptase (TERT), which
was derived from the consensus sequence from humans and primates and contains two
immunogenic mutations (SynCon TERT), with potential immunostimulating and antineoplastic
activities. Upon intramuscular administration of INO-1401 in combination with electroporation,
TERT protein is expressed and activates the immune system to mount a cytotoxic T-cell
(CTL) response against telomerase-expressing tumor cells, which may result in tumor
cell death. TERT is the catalytic subunit of telomerase and synthesizes telomeric
DNA at the chromosome ends. Telomerase prolongs the functional lifespan of cells via
the restoration and maintenance of telomere length. Abnormally activated in tumorigenesis,
TERT is expressed by many types of human cancer cells, but its expression is low or
non-existent in normal cells.;
Molecule name : INO-1401;
NCI Metathesaurus CUI : CL540179;
Origin ID : C142139;
UMLS CUI : C4722742;
Semantic type(s)
- concept_is_in_subset
- has_target
