" /> Autologous Genetically-modified MAGE-A4 C1032 CD8alpha T Cells - CISMeF





Preferred Label : Autologous Genetically-modified MAGE-A4 C1032 CD8alpha T Cells;

NCIt synonyms : MAGE-A4-specific TCR gene-transduced C1032 CD8alpha T-lymphocytes; Autologous Genetically-modified MAGE-A4 C1032 CD8alpha T Lymphocytes; MAGE-A4 SPEAR CD8alpha T-cells; Autologous Genetically-modified Melanoma Antigen A4 CD8alpha T Cells; Autologous MAGE-A4 C1032 TCR-modified CD8alpha T Cells; SPEAR T-cell ADP-A2M4CD8; Autologous TCR-transduced MAGE-A4 C1032 CD8alpha T Cells;

NCIt definition : Autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4) and the CD8alpha co-receptor, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous genetically-modified MAGE-A4 C1032 CD8alpha T-cells bind to tumor cells expressing MAGE-A4. This may result in both inhibition of growth and increased cell death of MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4, a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety of cancer cell types. Co-expression of CD8alpha may broaden the immune response against tumors and increase antitumor activity by converting CD4 helper T-cells into CD8 cytotoxic T-cells.;

Molecule name : ADP-A2M4CD8;

NCI Metathesaurus CUI : CL973182;

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15/05/2024


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