Autologous Anti-HPV-16 E6 T-cell Receptor Gene-engineered Peripheral Blood Lymphocytes

Preferred Label : Autologous Anti-HPV-16 E6 T-cell Receptor Gene-engineered Peripheral Blood Lymphocytes;

NCIt synonyms : Autologous Anti-HPV-16 E6 TCR Gene-engineered Peripheral Blood Lymphocytes; Autologous Anti-HPV-16 E6 TCR Gene-engineered PBLs;

NCIt definition : Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell receptor (TCR) that is specifically directed against the viral oncoprotein human papillomavirus type 16 (HPV-16) E6, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-HPV-16 E6 TCR gene-engineered PBLs bind to HPV-16 E6-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of HPV-16 E6-positive cancer cells. HPV-16 E6, a cell surface glycoprotein, is overexpressed by a variety of HPV-associated cancers and is absent from healthy human tissues.;

Details

Origin ID

C118850;

UMLS CUI

C3900005;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Protein E6, Human Papillomavirus Type 16 [NCIt concept]

Keyword's position in hierarchy(ies) :

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