" /> Autologous MuSK-CD3z/4-1BB-expressing Chimeric Autoantibody Receptor T-cells MuSK-CAART - CISMeF





Preferred Label : Autologous MuSK-CD3z/4-1BB-expressing Chimeric Autoantibody Receptor T-cells MuSK-CAART;

NCIt synonyms : Autologous Anti-MuSK-CD3z/4-1BB-expressing CAART MuSK-CAART; Autologous MuSK CAAR T-cells MuSK-CAART; Autologous MuSK-CD3z/4-1BB-expressing CAAR T-cells MuSK-CAART; Autologous MuSK CAAR-expressing T-cells MuSK-CAART; Autologous MuSK-CD3z/4-1BB-expressing CAART MuSK-CAART;

NCIt definition : A preparation of autologous T-lymphocytes that have been engineered to express a chimeric autoantibody receptor (CAAR) containing the autoantigen muscle, skeletal receptor tyrosine-protein kinase (MuSK; muscle-specific kinase) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunomodulatory activity. Upon administration, the autologous MuSK-CD3z/4-1BB-expressing CAAR T-cells MuSK-CAART specifically recognize and induce selective toxicity in aberrant B-cells expressing MuSK autoantibodies. This inhibits the production of MuSK autoantibodies. MuSK is a transmembrane protein expressed on skeletal muscle cell membrane that plays an important role in the formation and maintenance of the neuromuscular junction. MuSK autoantibodies are produced and expressed by aberrant B-cells in MuSK-associated myasthenia gravis.;

Molecule name : MuSK-CAART;

NCI Metathesaurus CUI : CL1794292;

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15/05/2024


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