Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TIL

Preferred Label : Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TIL;

NCIt synonyms : MSGV1AIB (Anti-MART-1 TCR) Retroviral Vector-Transduced Autologous TIL;

NCIt definition : Human tumor infiltrating lymphocytes (TIL) isolated from a melanoma patient and were engineered to react with the melanoma antigen MART-1 (Melanoma Antigen Recognized by T cells, also called Melan-A). These TILs are transfected with a retroviral vector encoding anti-MART-1 specific T-cell receptors, grown in culture, and then transferred back to the patient. These genetically modified TIL may recognize and halt the growth of MART-1-expressing melanoma cells.;

Molecule name : DMF5;

Details

Origin ID

C38137;

UMLS CUI

C1510930;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Melanoma Antigen Recognized by T-Cells 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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