Autologous CD19 CAR-expressing CD4 /CD8 T-cells MB-CART19.1

Preferred Label : Autologous CD19 CAR-expressing CD4 /CD8 T-cells MB-CART19.1;

NCIt synonyms : Autologous CD19 CAR-transduced CD4/CD8 Enriched T-cells MB-CART19.1; MB CART19.1;

NCIt definition : A preparation of CD4 and CD8 autologous T-lymphocytes transduced with the lentiviral vector pLTG1563 expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD19 CAR-expressing CD4 /CD8 T-cells MB-CART19.1 are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.;

Molecule name : MB-CART19.1;

NCI Metathesaurus CUI : CL1406220;

Details

Origin ID

C172103;

UMLS CUI

C5417890;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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