" /> Autologous CRISPR-Cas9 Engineered Regnase-1/SOCS1 Dual-edited Tumor Infiltrating Lymphocytes KSQ-004EX - CISMeF





Preferred Label : Autologous CRISPR-Cas9 Engineered Regnase-1/SOCS1 Dual-edited Tumor Infiltrating Lymphocytes KSQ-004EX;

NCIt synonyms : Autologous SOCS1/Regnase-1-edited TILs KSQ-004EX; Regnase-1/SOCS1 Dual-edited Human CRISPR/Cas9-engineered TILs KSQ-004EX; Autologous Engineered Tumor Infiltrating Lymphocytes KSQ-004EX; Autologous SOCS1/Regnase-1 Inactivated Engineered TILs KSQ-004EX; CRISPR/Cas9-edited SOCS1/Regnase-1 Gene-inactivated Autologous TILs KSQ-004EX; Autologous Dual-edit eTILs KSQ-004EX; Autologous eTILs KSQ-004EX; Autologous CRISPR-Cas9 Engineered TILs KSQ-004EX;

NCIt definition : A preparation of autologous tumor infiltrating lymphocytes (TILs) gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to inactivate both the endogenous genes suppressor of cytokine signaling 1 (SOCS1) and Regnase-1, with potential immunomodulating and antineoplastic activities. Upon infusion of the autologous CRISPR-Cas9 engineered Regnase-1/SOCS1 dual-edited TILs KSQ-004EX back into the patient, the cells specifically recognize, target and kill the patient's tumor cells. Inactivation of endogenous SOCS1 and Regnase-1 in the TILs increases responsiveness to cytokine signals, increases persistence and memory formation of TILs, and enhances anti-tumor responses.;

Molecule name : KSQ 004EX; KSQ 004; KSQ-004; KSQ-004EX;

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10/05/2025


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