" /> Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4 and CD8 T-cells FH-MCVA2TCR - CISMeF





Preferred Label : Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4 and CD8 T-cells FH-MCVA2TCR;

NCIt synonyms : Autologous CD8 and CD4 T-cells transduced with TCR A2-MCC1; FH-MCVA2TCR Autologous CD8 and CD4 T-cells Transduced with TCR A2-MCC1;

NCIt definition : A preparation of autologous CD4 and CD62L-expressing CD8 T-cells transduced with a third generation lentiviral vector (LV) to express the high affinity T-cell receptor (TCR) A2 -MCC1, specific for the human leukocyte antigen (HLA)-A02-restricted Merkel cell polyomavirus (MCPyV; MCV) viral oncoprotein, with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, the autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD8 and CD4 T-cells FH-MCVA2TCR selectively bind to the KLLEIAPNC epitope (KLL epitope) within the MCPyV viral oncoprotein. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the MCPyV viral oncoprotein. Additionally, tumor-specific HLA-A02-restricted CD4 cells promote class I-restricted CD8 proliferation, survival and effector functions by producing interleukin (IL)-2 and facilitating the activation of dendritic cells (DCs). MCPyV viral oncoprotein is highly expressed in Merkel cell carcinoma (MCC) caused by MCPyV.;

Molecule name : FH-MCVA2TCR;

NCI Metathesaurus CUI : CL563078;

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02/05/2025


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