NCIt definition : A preparation of autologous, engineered T-lymphocytes that express both a second-generation
chimeric antigen receptor (CAR) specific for the human gastric carcinoma-associated
antigen MG7, and the co-stimulatory molecule 4-1BB (CD137), with potential antineoplastic
activity. Upon intratumoral injection, the autologous anti-MG7-CAR T-lymphocytes target
and attach to cancer cells expressing MG7. This induces selective toxicity in and
causes lysis of MG7-expressing tumor cells. MG7, a glycosylated protein sequence from
the tumor-associated antigen (TAA) carcinoembryonic antigen (CEA), plays a key role
in the development of certain tumor cell types. 4-1BB enhances T-cell activation and
signaling after recognition of MG7.;