Preferred Label : Autologous EGFRt/BCMA-41BBz-targeted CAR T Cells;
NCIt synonyms : B-cell Maturation Antigen-Targeted EGFRt/BCMA-41BBz CAR-modified T Cells; Autologous EGFRt/BCMA-41BBz CAR T Cell;
NCIt definition : A preparation of autologous T-lymphocytes transduced with a retroviral vector expressing
a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA)
human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily
member 17; TNFRSF17) fused to the co-stimulatory domain of 4-1BB (CD137) and the CD3-zeta
(CD3z) T-cell signaling domain, and a truncated form of the human epidermal growth
factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities.
Upon intravenous administration, autologous EGFRt/BCMA-41BBz-targeted CAR T cells
are directed to, and induce selective toxicity in, BCMA-expressing tumor cells. Devoid
of both ligand-binding domains and tyrosine kinase activity, the expressed EGFRt facilitates
in vivo detection of the administered, transduced T-cells and, if the administered
T-cells cause unacceptable side effects, can promote elimination of those cells through
a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. The
4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor
activity. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell
activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily
(TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces
of plasma cells and is overexpressed on malignant plasma cells.;
NCI Metathesaurus CUI : CL550780;
Origin ID : C148168;
UMLS CUI : C4724868;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
