NCIt definition : A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral
vector encoding a T-cell receptor (TCR) specific for an as of yet not identified tumor-associated
antigen (TAA), with potential antineoplastic activity. Upon intravenous administration
back into the patient, the autologous TCR-engineered T-cells IMA201 specifically recognize
and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated
immune response against the TAA-positive cancer cells.;