NCIt synonyms : Hsp70-peptide TKD/IL-2-activated Autologous NK Cells;
NCIt definition : A preparation of autologous natural killer (NK) cells that are stimulated ex vivo
by a 14-mer heat shock protein 70 (Hsp70) TKD peptide and interleukin-2 (IL-2), with
potential tumor-selective cytolytic activity. Upon re-infusion into the patient, the
treated NK cells recognize and bind to Hsp70-expressing tumor cells, which induces
NK-mediated tumor cell lysis. Hsp70, a membrane-bound, stress-inducible protein, is
overexpressed on almost all tumor cells; however, it is absent or minimally present
on normal, healthy cells. TKD is the C-terminal substrate-binding domain of Hsp70
and is the structure recognized by the activated NK cells.;