Autologous Anti-CD4 CAR T-cells LB1901

Preferred Label : Autologous Anti-CD4 CAR T-cells LB1901;

NCIt synonyms : Autologous CD4-specific CAR T Cells LB1901; Autologous CD4-Targeted Chimeric Antigen Receptor T-Cells LB1901; Autologous CAR T-cells LB1901;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD4, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD4 CAR T-cells LB1901 target and bind to CD4-expressing tumor cells, thereby inducing selective toxicity in CD4-expressing tumor cells. CD4 antigen is expressed in CD4-positive T-cell lymphomas.;

Molecule name : LB-1901; LB 1901;

NCI Metathesaurus CUI : CL1664795;

Details

Origin ID

C181700;

UMLS CUI

C5557204;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- T-Cell Surface Glycoprotein CD4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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