Recombinant Vaccinia-Mgp100 Vaccine

Preferred Label : Recombinant Vaccinia-Mgp100 Vaccine;

NCIt synonyms : r- Mgp100 Vaccine;

NCIt definition : A recombinant vaccinia virus encoding a modified peptide of the gp100 melanoma-melanocyte antigen with potential use in cancer immunotherapy. gp100 human antigen is a wild type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas. This recombinant vaccinia Mgp100 encodes a fragment epitope of gp100 bearing 2 amino acids substitution; T- M at position 210 and 288 A - V at position 210. This modification may stimulate tumor infiltrating lymphocytes (TIL) more efficiently.;

NSC code : 697853;

Details

Origin ID

C51978;

UMLS CUI

C1709859;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Gene Regulation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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