Fowlpox-PSA-TRICOM Vaccine

Preferred Label : Fowlpox-PSA-TRICOM Vaccine;

NCIt synonyms : fPSA-TRI;

NCIt definition : A cancer vaccine consisting of a recombinant fowlpox virus encoding human prostate-specific antigen (PSA) and TRICOM, a combination of three immunostimulants (i.e., B7.1, ICAM-1, and LFA-3). Administration of this agent may induce a cytotoxic T cell response against PSA-expressing tumor cells. Dendritic cells infected with TRICOM vectors greatly enhance naive T-cell activation and peptide-specific T-cell stimulation. Fowlpox virus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells.;

Details

Origin ID

C38708;

UMLS CUI

C1327972;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Gene Regulation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
is_component_of_chemotherapy_regimen
- Fowlpox-PSA-TRICOM Vaccine/Fowlpox-Sargramostim Vaccine/Vaccinia-Prostate-Specific Antigen-TRICOM Vaccine [NCIt concept]
- Fowlpox-PSA-TRICOM Vaccine/Sargramostim/Vaccinia-Prostate-Specific Antigen-TRICOM Vaccine [NCIt concept]
- Fowlpox-PSA-TRICOM Vaccine/Vaccinia-Prostate-Specific Antigen-TRICOM Vaccine [NCIt concept]

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