NCIt definition : A cell-based cancer vaccine composed of autologous monocyte-derived dendritic cells
(DCs) loaded with the human tumor-associated antigens (TAAs) mucin-1 (MUC1) and Wilms
tumor protein 1 (WT1), with potential immunomodulating and antineoplastic activities.
Upon vaccination, the MUC-1/WT1 peptide-primed autologous DCs expose the immune system
to MUC1 and WT1 peptides and may stimulate the host immune system to mount a cytotoxic
T-lymphocyte (CTL) response against MUC1 and WT1-expressing cancer cells, which could
result in cancer cell lysis. MUC1 and WT1, are overexpressed in a variety of tumor
types and play an important role in tumor cell proliferation.;