NCIt synonyms : Autologous Anti-HLA-G CAR T Cells IVS-3001; Autologous Anti-HLA-G CAR T-cells IVS-3001;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA)
and immune checkpoint protein human leukocyte antigen G (HLA-G), with potential immune
checkpoint inhibiting, immunomodulating and antineoplastic activities. Upon administration,
autologous anti-HLA-G CAR-T cells IVS-3001 specifically recognize and kill HLA-G-expressing
tumor cells. This reverts HLA-G-mediated immune suppression in the tumor microenvironment
(TME), thereby restoring anti-tumor immune responses. HLA-G, an immune checkpoint
normally expressed at the maternal-fetal interface, is expressed across multiple tumor
types and plays a key role in cancer immune evasion. It inhibits immune responses
by binding to its inhibitory receptors on a variety of immune cells, such as natural
killer cells (NKs), T- and B-lymphocytes, and dendritic cells (DCs).;