NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) specific for the T-cell surface glycoprotein CD1a,
with potential immunostimulating and antineoplastic activities. Upon administration,
autologous anti-CD1a CAR T cells bind to and induce selective toxicity in CD1a-expressing
tumor cells. CD1a, an antigen-presenting glycoprotein, is exclusively expressed in
cortical T-cell acute lymphoblastic leukemia (T-ALL) and otherwise only normally expressed
in developing cortical thymocytes and Langerhans cells.;