Preferred Label : Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes;
NCIt synonyms : CD19R(EQ)28zetaEGFRt Tn/mem Cells; CD19R(EQ)28zetaEGFRt Tn/Tmem;
NCIt definition : A preparation of genetically modified autologous lymphocytes comprised of CD62L-positive
naïve and memory T-cells (Tn/mem), that are transduced ex vivo with a self-inactivating
(SIN) lentiviral vector expressing a hinge-optimized chimeric antigen receptor (CAR)
specific for the CD19 antigen and containing CD28 and CD3 zeta signaling domains,
and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential
immunostimulating and antineoplastic activities. Upon isolation of peripheral blood
lymphocytes (PBLs), transduction of the CD62L-positive T-lymphocytes, expansion ex
vivo and reintroduction of the cells into the patient, the autologous CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing
Tn/mem-enriched T-cells target CD19-expressing tumor cells, thereby inducing selective
toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface
antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding
domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of
the administered T-cells and can promote elimination of those cells upon a cetuximab-induced
antibody dependent cellular cytotoxicity response. Tn/mem T-cells include naïve T-cells,
central memory T-cells (Tcm) and stem cell memory T-cells (Tscm). CD19R(EQ) contains
two point mutations in the immunoglobulin (Ig) G4 spacer region, thereby preventing
recognition of the CAR by Fc receptors (FcRs).;
Origin ID : C124795;
UMLS CUI : C4086002;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
