TNF Transduced TIL

Preferred Label : TNF Transduced TIL;

NCIt synonyms : TNF Gene Transduced TIL;

NCIt definition : A preparation of autologous tumor-infiltrating lymphocytes (TILs) that have been transduced with a retroviral vector encoding the gene for tumor necrosis factor (TNF), a cytokine with anti-angiogenic and cytotoxic activity. Following genetic modification, the lymphocytes are returned to the patient, infiltrate the tumor site, and deliver TNF directly to the tumor site, thereby exerting a specific antitumor effect, and avoiding TNF-related systemic toxicity. (NCI04);

Details

Origin ID

C29482;

UMLS CUI

C1515168;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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