Preferred Label : Autologous Deep IL-15 Primed T-cells TRQ15-01;
NCIt synonyms : IL-15 Loaded Autologous T-lymphocytes TRQ15-01;
NCIt definition : A preparation of genetically modified, multi-antigen-directed autologous T-lymphocytes,
that have particles, consisting of multiple chemically crosslinked human cytokine
interleukin-15 (IL-15)/IL-15 receptor alpha (IL-15Ra)/Fc heterodimers, attached to
their surface, with potential immunostimulating and antineoplastic activities. TRQ15-01
is made from monocyte-derived dendritic cells (moDCs) that are pulsed with peptides
from multiple tumor-associated antigens (TAAs) to expand cytotoxic T-lymphocytes (CTLs)
that are subsequently loaded with IL-15 particles. Upon administration of the autologous
deep IL-15 primed T-cells, the IL-15/IL-15Ra fusion proteins are slowly released in
vivo from the T-cells in a controlled manner and induce autocrine cytokine stimulation
of the administered T-cells, thereby increasing T-cell division of the administered
T-cells. The expanded T-cells target, bind to and kill tumor cells. This increases
tumor cell growth inhibition by T-cells. IL-15 is a pro-survival, inflammatory cytokine
and causes sustained T-cell expansion and enhanced anti-tumor activity. Compared to
systemically delivered IL-15, IL-15 attached to the T-cells greatly increases target
CD8 T-cell concentrations in the tumor, without significant systemic effects.;
Molecule name : TRQ15-01;
NCI Metathesaurus CUI : CL937688;
Origin ID : C158091;
UMLS CUI : C4764041;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
