" /> Autologous Anti-BCMA CAR T-cells MCARH125 - CISMeF





Preferred Label : Autologous Anti-BCMA CAR T-cells MCARH125;

NCIt synonyms : Autologous BCMA-directed CAR-T Cells MCARH125; Autologous BCMA-targeted CAR T Cell MCARH125; Autologous BCMA-specific CAR T-cells MCARH125;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential antineoplastic activity. Upon administration, the autologous anti-BCMA CAR T-cells MCARH125 recognize and induce selective toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells.;

Molecule name : MCAR H125; MCAR-H125;

NCI Metathesaurus CUI : CL1793075;

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15/05/2024


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