Autologous Anti-CD1a CAR T Cells OC-1

Preferred Label : Autologous Anti-CD1a CAR T Cells OC-1;

NCIt synonyms : Autologous Anti-CD1a CAR-T Cells OC-1; Autologous Anti-CD1a CAR T-cells OC-1; Autologous hCD1a-CAR T Cells OC-1;

NCIt definition : A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the T-cell surface glycoprotein CD1a, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD1a CAR T cells OC-1 bind to and induce selective toxicity in CD1a-expressing tumor cells. CD1a, an antigen-presenting glycoprotein, is exclusively expressed in cortical T-cell acute lymphoblastic leukemia (T-ALL) and otherwise only normally expressed in developing cortical thymocytes and Langerhans cells.;

Molecule name : OC 1; OC-1;

NCI Metathesaurus CUI : CL1906530;

Details

Origin ID

C199631;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- T-Cell Surface Glycoprotein CD1a [NCIt concept]

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