MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201 - CISMeF
MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201NCIt concept
Preferred Label : MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201;
NCIt definition : Autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell
receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4), with potential
immunostimulatory and antineoplastic activities. Upon isolation, transduction, expansion
ex vivo, and reintroduction into the patient, MAGE-A4-specific TCR gene-transduced
T-lymphocytes TBI-1201 binds to tumor cells expressing MAGE-A4. This may result in
both an inhibition of growth and increased cell death for MAGE-A4-expressing tumor
cells. The tumor-associated antigen MAGE-A4 is overexpressed by a variety of cancer
cell types.;