" /> Autologous mRNA-transfected Anti-BCMA-CAR T-lymphocytes SYS6020 - CISMeF





Preferred Label : Autologous mRNA-transfected Anti-BCMA-CAR T-lymphocytes SYS6020;

NCIt synonyms : Autologous mRNA-Lipid Nanoparticles-based Anti-BCMA CAR T-cells SYS6020; Autologous BCMA-targeted CAR T-cells SYS6020; Autologous mRNA-LNP-based Anti-BCMA CAR-T Cells SYS6020;

NCIt definition : A preparation consisting of autologous T-lymphocytes that have been transfected with lipid nanoparticle (LNP)-mRNA encoding for a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and containing as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous mRNA-transfected anti-BCMA-CAR T-lymphocytes SYS6020 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells.;

Molecule name : SYS-6020; SYS 6020;

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30/07/2025


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