" /> Autologous IL-12/Multi-targeted Primed T-cells RPTR 168 - CISMeF





Preferred Label : Autologous IL-12/Multi-targeted Primed T-cells RPTR 168;

NCIt synonyms : Autologous IL-12-expressing MTC RPTR 168; Autologous IL-12/Multi-targeted Primed T-lymphocytes RPTR 168; PRIME IL-12;

NCIt definition : A preparation of genetically modified, multi-antigen-targeted autologous T-lymphocytes, tethered with the human immunostimulatory cytokine interleukin-12 (IL-12), with potential immunostimulating and antineoplastic activities. RPTR 168 is prepared from monocyte-derived dendritic cells (moDCs) that are pulsed with five tumor-associated antigens (TAAs) to expand cytotoxic T-lymphocytes (CTLs) that are subsequently loaded with IL-12. Upon administration, the autologous IL-12/multi-targeted primed T-cells RPTR 168 specifically target tumor cells expressing the five TAAs, which lead to a specific cytotoxic T-lymphocyte (CTL)-mediated killing of these tumor cells. In addition, IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFN-g), activating natural killer cells (NKs), and inducing CTL responses, which may further increase tumor cell death and decrease tumor cell proliferation.;

Molecule name : RPTR 168; RPTR-168;

NCI Metathesaurus CUI : CL1662403;

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10/05/2024


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